Some people guess that DNP NMR is a cost-prohibitive method of analysis.
We believe that DNP NMR should be affordable and available for all laboratories and should be easy to maintain.
By clicking on this image, you will be forwarded to web interface of Elegant NMR spectrometer.
Compact configuration: the Elmathron® is equipped with the computational server.
Standard configuration: one Elmathron® is connected to one computational server.
Parallel configuration: several Elmathron® devices are connected to one computational server.
The Elegant NMR® system is not intended to work on the following conditions:
the pressure at the inlet of your vacuum line rises above the permissible value denoted on the technical data sheet;
a strong magnetic field source or ferromagnet comes into the immediate vicinity of the Elmathron device;
strong acid, magnetic fluid, fluid with particles, glue, fast polymerizing substances enters the inlet of the Elmathron measuring device;
the pressure at the inlet of the Elmathron measuring device rises above/below the permissible value denoted on the technical data sheet.
In such situations, the main icon Status of All Devices and Server of Elegant NMR® Software
will change its color to red:
Getting Started Presentation
FAQ
Q:What is the magnetic strength in Tesla?
A: We use very weak magnets, only 1 T, because DNP in liquids only works well with magnetic fields less than 1 T. In turn, DNP improves the signal-to-noise
ratio for one-dimensional spectra by about 400 times, and almost 100,000 times for multidimensional spectra. Therefore, the sensitivity of 1D is approximately as
if we were capturing spectra at 100 MHz, and the sensitivity of 2D+ is approximately as if we were capturing spectra at 400 MHz.
Q:Can I get 1D spectra from Elegant NMR system?
A: The ability of the Elegant NMR measuring system to automatically interpret heteronuclear DNP NMR spectra on an adaptive grid completely disrupts the status quo
in which 7- and 8-dimensional DNP NMR spectra, having sparsity values less than 0.1%, are very difficult not only to interpret, but even to visualize.
In the Elegant NMR system, such spectra are identified with reference to a huge database containing about 1.7 billion spatial molecular structures.
7-8-dimensional spectra can be projected onto one-dimensional slices and then visualized. We will implement this approach in the expert mode of the Elegant NMR software
for reference purposes.
Q:Do we need to use external MW source for DNP?
A: No, Elegant NMR System is equipped with internal DNP source according to recently patented technology US 10773092 B2.
Q:Do you have HPLC/GC-MS inside, or how you separate unknown mixtures?
A: We do not separate molecules, we separate signals.
In classical HPLC, for separation to occur, we need the substances to be separated to form complexes with a stationary phase and the energy of formation of such complexes
is significantly different. It is often possible to find a stationary phase that would orientate the substances to be separated well, but would not separate these mixtures
well enough, for instance, because of the insufficient number of theoretical plates. In our apparatus we do not separate substances, namely, we orient them differently.
This orientation affects the two-dimensional NMR spectra and it is possible, without separation, to obtain slightly different HSQC or NOE spectra, and on the basis of
their correlations, to get relative concentration and pure spectra of the substances themselves.
The patent pending technology US 16/695,200 is fully implemented inside Elegant NMR system.
Coming Soon: This is a special web page to track known bugs and expected improvements in the Elegant NMR® Software.
If you want to report bug, or suggest improvements, please, do not hesitate to send a e-mail to development at elegant-nmr dot com with the subject "ElegantNMR". We will report you regarding to this bug/improvement and if, confirmed, append to this list.
In addition, feel free to suggest interesting measurements for chemical reactions - we will perform soon several online test measurements.
Fixed bugs or completed improvements will be removed from the list, and the author, who has reported first this bug will be notified.
You can also subscribe/unsubscribe to/from the updates in this list sending e-mail to the same e-mail address with a message subscribe/unsubscribe.
Several bugs in the software or firmware of the Elegant NMR system that are not directly visible in the Web Interface but known for developers and beta testers are not reported for public and is distributed only by this e-mail subscriptions.
Current list of bugs and improvements for v1.08:
Continious Measurements Screen
"Stop if No Change" option should be forwarded into Advanced Parameters Screen as "StopNC" parameter in parallel to Supress/Amplify. Manual. Deadline 12/2021.
Measurements with Autosampler Screen
Restrict identical names in the Autosampler. Deadline Q1/2023.
Manual for names of each probe: how to store large names. Deadline Q1/2023.
Search Records Screen
Connect to read data base. Deadline 12/2021.
Data back up and archiving. We should implement data archiving outside main archive and import data from external source into the database. Manual. Deadline Q1/2022.
Run Computations Screen
In the Advanced Parameters subsection, instead of Aplify/Supress, we should implement Only/Exclude and describe them in the manual. Manual. Deadline 12/2021.
Results of Computations Screen
Append confidence range for every computed dataset. Place checkbox to switch it on/off. Manual. Deadline 12/2021.
Append confidence range for the approximation itself. Manual. Deadline 12/2021.
Device Settings Screen
Connect web interface to real device. Deadline Q1/2022.
Status Screen
Connect to real device. Deadline Q1/2022.
Info Screen
Place demo examples screen. Deadline 12/2021.
Put several examples here. Deadline Q1/2022.
Key Idea
The ELEGANT NMR® incorporates the following advantages:
Several-fold reduction of component costs due to a new processing method,
Several-fold reduction in magnet size (US Patent: US10646722B2),
Detection of most to all visible chemical elements and their NMR spectra in the investigated area using an advanced synchronization processing method,
Drastically increased sensitivity due to dynamic nuclear polarization (DNP), needing only about 100 nL fluid to perform detection
(US Patent: US10773092B2),
Improved spectrum quality and matching to database using an automatic procedure for well-known multidimensional HSQC and NOESY methods,
Drastically accelerated spectrum acquisition due to a non-uniform sampling (NUS) method,
An automatic procedure by AI for matching spectra to a predetermined reference database without deep understanding of NMR analysis, including in
situations with different solvents, using a well-known least squares method,
An automatic procedure for analyzing chemical mixtures without a priori knowledge, even if the concentration changes during measurement, by using
an advanced method for multilinear decomposition of spectra without predetermined references,
and many other useful features, such as solvent suppression and measurement of droplet size, flow, temperature, pressure, and density, that help
to reduce the count of additional instruments needed for analyses.
The recently-patented Elegant NMR technologies for the production of uniform and focused permanent magnets, as well as for the creation of dual-band dynamic
nuclear polarization (DNP), make possible a new generation of nuclear magnetic resonance (NMR) spectrometers with nanoscale measuring range. That is, one
nanomole of the substance under study is sufficient for the collection of DNP-NMR spectra and unambiguous identification.
In addition, patent-pending combined NMR and chromatography technology allows the simultaneous detection of a large number of chemicals in a mixture whose
respective concentrations are in the nanomolar range.
Magnet production using patented technology US 10646722 B2.
Each Elmathron® device contains all the necessary electronics for DNP and signal processing, all signal transmitters and receivers for all existing non-zero spin isotopes.
The device includes 4 square meters of printed circuit boards that are fully engineered in Elegant Mathematics LLC.
Elegant Mathematics LLC performs complete software and hardware development.
Most of the components (about 70%) are from US manufacturers and final assembly is done in Germany.
Applications
Easy to operate:
WebApp for remote control of all analyses and operations;
No additional knowledge needed - the device can match unknown substances and deliver their chemical formulas and concentrations;
Includes separation of substances in investigated mixture (patent pending) - each measurement yields a list of substances and their concentrations;
no additional knowledge of multidimensional NMR needed!
Now, this easy-to-use NMR technology is available for:
medical and pharmaceutical industry: an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases,
universities and research institutions: for real-time monitoring of chemical synthesis,
chemical and oil/gas industries: for real-time, monitoring of droplet size, chemical processes, and quality control,
beverage and food industries: for real-time quality control,
industrial automation: for real-time quality control.
Suitable for nearly all chemical reactions, the Elegant NMR provides real-time monitoring of key information, allowing advanced understanding
and control of reactions.
Elegant Mathematics' innovative technologies are protected by the following patents:
US 10,646,722 B2 Production of homogeneous and focused permanent magnets from commonly available magnetic material,
free of rare earth elements.
US 10,773,092 B2 A dual-band DNP-NMR method with no need to use very expensive turbomolecular pumps, liquid helium
to cool the magnets, or other cryogenic methods.
US 10,773,093 B2 A method of non-invasive magnetic resonance imaging, non-invasive heating, and non-invasive ablation.
And a plurality of patent pending applications. All of this allowed Elegant Mathematics Team to progress to the stage of production of
a DNP NMR device capable of measuring a multicomponent mixture of organic substances with constituent concentrations in the nanomolar
range and determining its molecular and isotopic composition along with the concentrations of its components.
ELEGANT NMR® (in use since Aug 2016)
ELMATHRON® (in use since Dec 2016)
are all registered trademarks of Elegant Mathematics LLC.
COVID-19 and Lung Diseases: Express and Inexpensive Analysis of Exhaled Air by Nano-Volume DNP-NMR
In the time of the present coronavirus pandemic, we should all collectively react both fast and appropriately.
The Elegant Mathematics Team proposes an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases.
The developed analyzer allows assays to be carried out in the early stages of disease,
allows the prediction of disease, and can also be used during treatment to collect additional statistics,
monitor progression, and improve the quality of treatment received.
Elegant Mathematics recently-patented technologies for the production of uniform and focused permanent magnets,
as well as for the creation of dual-band dynamic nuclear polarization (DNP), make possible a new generation of nuclear magnetic resonance (NMR) spectrometers
with nanoscale measuring range. That is, one nanomole of the substance under study is sufficient for the collection of DNP-NMR spectra and unambiguous identification.
In addition, recently-patented combined NMR and chromatography technology allows the simultaneous detection of a large number of chemicals
in a mixture whose respective concentrations are in the nanomolar range.
Fast and inexpensive testing for COVID-19 and associated lung disease is essential today. Exhaled air contains many chemical markers—small organic molecules,
usually less than 200 Da—with concentrations of 1 ppb - 100 ppm, and combinations of these markers are characteristic of particular types and stages of disease.
Indeed, chemical analysis of the air exhaled by a person is a well-established method for the determination of many diseases,
and relevant databases have been created and are publicly available.
The key problem that hinders the widespread use of this method is the low abundance of any given constituent in the mixture
of substances released into the air from a person’s lungs. For example, toluene and acetone are among the most abundant compounds in exhaled air,
but still have concentrations of only around 10 ppm. Other components are usually in the range of 1-10 ppm. Furthermore,
while there are many methods for the chemical analysis of gases, such as using metal oxide sensors, the most accurate is to use gas chromatography
in combination with mass spectroscopic detection—which method is also very expensive.
Recent developments by Elegant Mathematics company in the field of nuclear magnetic resonance, in particular the combination of NMR with chromatography and with DNP,
allowed us to create a benchtop-sized NMR device capable of conducting chemical analysis of liquid volumes up to 1 nl and gas volumes of 1 μl
at room temperature with a detection level in the nanomole range.
Elegant NMR Project proposes an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases.
The developed analyzer allows assays to be carried out in the early stages of disease, allows the prediction of disease,
and can also be used during treatment to collect additional statistics, monitor progression, and improve the quality of treatment received.
Considering that one measurement can be performed in a period of about 10-200 seconds, and there are no additional costs for the mobile phase,
chromatographic columns, gases, etc., if the device is operated 24 hours a day for 3 years, the cost of its operation is about 10 cents per measurement.
Thus, Elegant NMR devices can be used in the place of expensive GC-MS devices for the inexpensive and rapid analysis of human exhaled air.
Such a low cost of analysis will provide for a virtually unlimited number of opportunities for conducting preventive medical testing
as well as preserving health, tuning medical treatments, and thereby saving many lives.
About Elegant Mathematics
1992 Incorporation of Elegant Mathematics Inc. in Bothell, USA (reg. nr. 601360776), active as the main supercomputer software supplier for Cray Research Inc.
2006 Relocated to Germany and the EU (as Elegant Mathematics Ltd)
2006 Since 2006 Elegant Mathematics Ltd has previously been involved in several gas detection projects alongside E-Nose (NL) and NXP;
ground penetrating radar Tier 1 development, and CUDA projects:
Nvidia GPU supercomputer solutions consulting
2017 Incorporation of Elegant Mathematics LLC, mainly for ELEGANT NMR® activity
2020 Elegant Mathematics LLC has received 3 US patents for key NMR technologies
2020 Elegant Mathematics combined NMR and chromatography technology allows the simultaneous detection of a large number of chemicals in a mixture whose
respective concentrations are in the nanomolar range, and makes possible a new generation of nuclear magnetic resonance spectrometers with nanoscale
measuring range (Elegant NMR with Elmathron)
Order Terms
Elegant Mathematics standard condition of sales and payments is:
30% - when placing the order;
30% - once the equipment has been completely assembled and tested ex-works Germany;
20% - to be paid after witnessing and acceptance of full function of your specific equipment;
20% - final payment after inspect and testing at the customers facility.
All invoices are due and payable in cash in EU or US currency. All payments due to Elegant Mathematics shall be made by bank wire transfer.
Warranty
Elegant Mathematics service includes free Elegant NMR® Software updates for eight years after purchase.
The warranty period for the basic version of the Elegant NMR® system is two years, subject to purchase from the manufacturer's warehouse and paid mandatory intermediate inspection after one year of operation.
The warranty period can be extended to as much as five years by passing paid annual inspections of the measuring system.
The warranty period starts from the moment the customer receives the Elegant NMR® system.
You may order a vacuum pump from us together with the system, use one already present in your laboratory, or buy one separately from a third-party company of your choice.
The vacuum pump supplied with the Elegant NMR® measuring system is not covered by the Elegant Mathematics warranty.
Our Contacts
Elegant Mathematics LLC,
82834, WY, USA Tel: +1 (631) 490 - 0521 Email: info at elegant - mathematics dot com
Elegant Mathematics Ltd,
Hanauer Muehle 2,
66564, Ottweiler-Fuerth,
Saarland Germany Tel: +49 (6858) 79 79 858 Email: info at elegant - math dot de
Legal registration numbers:
USA: Cheyenne 746213
UK: Cardiff 05975337
DE: HRB 16570
Active and registered since 23 Oct 2006
German tax payer's account number 030/146/00565
EU VAT account number DE 257663693
Customs number (EORI) DE 1753525
According to Par 2 Abs. 2 ElektroG, our Elegant NMR is a pure Research and Development device for university and industrial usage only; it is therefore available free from
the WEEE in the EU.
Our technical support and information office is always available for you. You can contact us at any time from any point in the world by phone and
receive competitive guidance and consulting on our products and services. Please also use our ResearchGate Project Page
to discuss aspects of the Elegant NMR, along with general questions on applied mathematics, physics, and chemistry related to NMR.
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Elegant-NMR.de.
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