COVID-19 and Lung Diseases: Express and Inexpensive Analysis of Exhaled Air by Nano-Volume DNP-NMR
In the time of the present coronavirus pandemic, we should all collectively react both fast and appropriately.
The Elegant Mathematics Team proposes an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases.
The developed analyzer allows assays to be carried out in the early stages of disease,
allows the prediction of disease, and can also be used during treatment to collect additional statistics,
monitor progression, and improve the quality of treatment received.
Elegant Mathematics recently-patented technologies for the production of uniform and focused permanent magnets,
as well as for the creation of dual-band dynamic nuclear polarization (DNP), make possible a new generation of nuclear magnetic resonance (NMR) spectrometers
with nanoscale measuring range. That is, one nanomole of the substance under study is sufficient for the collection of DNP-NMR spectra and unambiguous identification.
In addition, recently-patented combined NMR and chromatography technology allows the simultaneous detection of a large number of chemicals
in a mixture whose respective concentrations are in the nanomolar range.
Fast and inexpensive testing for COVID-19 and associated lung disease is essential today. Exhaled air contains many chemical markers—small organic molecules,
usually less than 200 Da—with concentrations of 1 ppb - 100 ppm, and combinations of these markers are characteristic of particular types and stages of disease.
Indeed, chemical analysis of the air exhaled by a person is a well-established method for the determination of many diseases,
and relevant databases have been created and are publicly available.
The key problem that hinders the widespread use of this method is the low abundance of any given constituent in the mixture
of substances released into the air from a person’s lungs. For example, toluene and acetone are among the most abundant compounds in exhaled air,
but still have concentrations of only around 10 ppm. Other components are usually in the range of 1-10 ppm. Furthermore,
while there are many methods for the chemical analysis of gases, such as using metal oxide sensors, the most accurate is to use gas chromatography
in combination with mass spectroscopic detection—which method is also very expensive.
Recent developments by Elegant Mathematics company in the field of nuclear magnetic resonance, in particular the combination of NMR with chromatography and with DNP,
allowed us to create a benchtop-sized NMR device capable of conducting chemical analysis of liquid volumes up to 1 nl and gas volumes of 1 μl
at room temperature with a detection level in the nanomole range.
Elegant NMR Project proposes an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases.
The developed analyzer allows assays to be carried out in the early stages of disease, allows the prediction of disease,
and can also be used during treatment to collect additional statistics, monitor progression, and improve the quality of treatment received.
Considering that one measurement can be performed in a period of about 10-200 seconds, and there are no additional costs for the mobile phase,
chromatographic columns, gases, etc., if the device is operated 24 hours a day for 3 years, the cost of its operation is about 10 cents per measurement.
Thus, Elegant NMR devices can be used in the place of expensive GC-MS devices for the inexpensive and rapid analysis of human exhaled air.
Such a low cost of analysis will provide for a virtually unlimited number of opportunities for conducting preventive medical testing
as well as preserving health, tuning medical treatments, and thereby saving many lives.
Our Contacts
Elegant Mathematics LLC,
82834, WY,
USA
Tel: +1 (631) 490 - 0521
Email: info at elegant - mathematics dot com
Elegant Mathematics Ltd,
Hanauer Muehle 2,
66564, Ottweiler-Fuerth,
Saarland
Germany
Tel: +49 6858 79 79 858
Email: info at elegant - math dot de
Legal registration numbers:
USA: Cheyenne 746213
UK: Cardiff 05975337
DE: HRB 16570
Active and registered since 23 Oct 2006
German tax payer's account number 030/146/00565
EU VAT account number DE 257663693
Customs number (EORI) DE 1753525
According to Par 2 Abs. 2 ElektroG, our Elegant NMR is a pure Research and Development device for university and industrial usage only; it is therefore available free from
the WEEE in the EU.
Our technical support and information office is always available for you. You can contact us at any time from any point in the world by phone and receive competitive
guidance and consulting on our products and services. Please also use
our ResearchGate Project Page
to discuss aspects of the Elegant NMR, along with general questions on applied mathematics, physics, and chemistry related to NMR.
Disclaimer: By providing links to other sites, Elegant-NMR.com, Elegant-NMR.de, Elegant Mathematics Ltd, and Elegant Mathematics LLC do not guarantee, approve,
or endorse the information or products available at those sites, nor does a link indicate any association with or endorsement by the linked site of Elegant-NMR.com or
Elegant-NMR.de.
© Copyright Elegant Mathematics LLC 2006-2020. All rights reserved. Page last updated: Feb 2021
