Early-bird offer: special promo price, only until August 13, 2021!
Some people guess that DNP NMR is a cost-prohibitive method of analysis.
We believe that DNP NMR should be affordable and available for all laboratories and should be easy to maintain.
By clicking on this image, you will be forwarded to web interface of Elegant NMR spectrometer.
Compact configuration: the Elmathron® is equipped with the computational server.
Standard configuration: one Elmathron® is connected to one computational server.
Parallel configuration: several Elmathron® devices are connected to one computational server.
Key Idea
The ELEGANT NMR® incorporates the following advantages:
Several-fold reduction of component costs due to a new processing method,
Several-fold reduction in magnet size (US Patent: US10646722B2),
Detection of most to all visible chemical elements and their NMR spectra in the investigated area using an advanced synchronization processing method,
Drastically increased sensitivity due to dynamic nuclear polarization (DNP), needing only about 100 nL fluid to perform detection
(US Patent: US10773092B2),
Improved spectrum quality and matching to database using an automatic procedure for well-known multidimensional HSQC and NOESY methods,
Drastically accelerated spectrum acquisition due to a non-uniform sampling (NUS) method,
An automatic procedure by AI for matching spectra to a predetermined reference database without deep understanding of NMR analysis, including in
situations with different solvents, using a well-known least squares method,
An automatic procedure for analyzing chemical mixtures without a priori knowledge, even if the concentration changes during measurement, by using
an advanced method for multilinear decomposition of spectra without predetermined references,
and many other useful features, such as solvent suppression and measurement of droplet size, flow, temperature, pressure, and density, that help
to reduce the count of additional instruments needed for analyses.
The recently-patented Elegant NMR technologies for the production of uniform and focused permanent magnets, as well as for the creation of dual-band dynamic
nuclear polarization (DNP), make possible a new generation of nuclear magnetic resonance (NMR) spectrometers with nanoscale measuring range. That is, one
nanomole of the substance under study is sufficient for the collection of DNP-NMR spectra and unambiguous identification.
In addition, patent-pending combined NMR and chromatography technology allows the simultaneous detection of a large number of chemicals in a mixture whose
respective concentrations are in the nanomolar range.
Magnet production using patented technology US 10646722 B2.
Each Elmathron® device contains all the necessary electronics for DNP and signal processing, all signal transmitters and receivers for all existing non-zero spin isotopes.
The device includes 4 square meters of printed circuit boards that are fully engineered in Elegant Mathematics LLC.
Elegant Mathematics LLC performs complete software and hardware development.
Most of the components (about 70%) are from US manufacturers and final assembly is done in Germany.
Applications
Easy to operate:
WebApp for remote control of all analyses and operations;
No additional knowledge needed - the device can match unknown substances and deliver their chemical formulas and concentrations;
Includes separation of substances in investigated mixture (patent pending) - each measurement yields a list of substances and their concentrations;
no additional knowledge of multidimensional NMR needed!
Now, this easy-to-use NMR technology is available for:
medical and pharmaceutical industry: an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases,
universities and research institutions: for real-time monitoring of chemical synthesis,
chemical and oil/gas industries: for real-time, monitoring of droplet size, chemical processes, and quality control,
beverage and food industries: for real-time quality control,
industrial automation: for real-time quality control.
Suitable for nearly all chemical reactions, the Elegant NMR provides real-time monitoring of key information, allowing advanced understanding
and control of reactions.
Elegant Mathematics' innovative technologies are protected by the following patents:
US 10,646,722 B2 Production of homogeneous and focused permanent magnets from commonly available magnetic material,
free of rare earth elements.
US 10,773,092 B2 A dual-band DNP-NMR method with no need to use very expensive turbomolecular pumps, liquid helium
to cool the magnets, or other cryogenic methods.
US 10,773,093 B2 A method of non-invasive magnetic resonance imaging, non-invasive heating, and non-invasive ablation.
And a plurality of patent pending applications. All of this allowed Elegant Mathematics Team to progress to the stage of production of
a DNP NMR device capable of measuring a multicomponent mixture of organic substances with constituent concentrations in the nanomolar
range and determining its molecular and isotopic composition along with the concentrations of its components.
ELEGANT NMR® (in use since Aug 2016)
ELMATHRON® (in use since Dec 2016)
are all registered trademarks of Elegant Mathematics LLC.
COVID-19 and Lung Diseases: Express and Inexpensive Analysis of Exhaled Air by Nano-Volume DNP-NMR
In the time of the present coronavirus pandemic, we should all collectively react both fast and appropriately.
The Elegant Mathematics Team proposes an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases.
The developed analyzer allows assays to be carried out in the early stages of disease,
allows the prediction of disease, and can also be used during treatment to collect additional statistics,
monitor progression, and improve the quality of treatment received.
Elegant Mathematics recently-patented technologies for the production of uniform and focused permanent magnets,
as well as for the creation of dual-band dynamic nuclear polarization (DNP), make possible a new generation of nuclear magnetic resonance (NMR) spectrometers
with nanoscale measuring range. That is, one nanomole of the substance under study is sufficient for the collection of DNP-NMR spectra and unambiguous identification.
In addition, recently-patented combined NMR and chromatography technology allows the simultaneous detection of a large number of chemicals
in a mixture whose respective concentrations are in the nanomolar range.
Fast and inexpensive testing for COVID-19 and associated lung disease is essential today. Exhaled air contains many chemical markers—small organic molecules,
usually less than 200 Da—with concentrations of 1 ppb - 100 ppm, and combinations of these markers are characteristic of particular types and stages of disease.
Indeed, chemical analysis of the air exhaled by a person is a well-established method for the determination of many diseases,
and relevant databases have been created and are publicly available.
The key problem that hinders the widespread use of this method is the low abundance of any given constituent in the mixture
of substances released into the air from a person’s lungs. For example, toluene and acetone are among the most abundant compounds in exhaled air,
but still have concentrations of only around 10 ppm. Other components are usually in the range of 1-10 ppm. Furthermore,
while there are many methods for the chemical analysis of gases, such as using metal oxide sensors, the most accurate is to use gas chromatography
in combination with mass spectroscopic detection—which method is also very expensive.
Recent developments by Elegant Mathematics company in the field of nuclear magnetic resonance, in particular the combination of NMR with chromatography and with DNP,
allowed us to create a benchtop-sized NMR device capable of conducting chemical analysis of liquid volumes up to 1 nl and gas volumes of 1 μl
at room temperature with a detection level in the nanomole range.
Elegant NMR Project proposes an easy-to-use and affordable method for the detection of COVID-19 infection and other lung diseases.
The developed analyzer allows assays to be carried out in the early stages of disease, allows the prediction of disease,
and can also be used during treatment to collect additional statistics, monitor progression, and improve the quality of treatment received.
Considering that one measurement can be performed in a period of about 10-200 seconds, and there are no additional costs for the mobile phase,
chromatographic columns, gases, etc., if the device is operated 24 hours a day for 3 years, the cost of its operation is about 10 cents per measurement.
Thus, Elegant NMR devices can be used in the place of expensive GC-MS devices for the inexpensive and rapid analysis of human exhaled air.
Such a low cost of analysis will provide for a virtually unlimited number of opportunities for conducting preventive medical testing
as well as preserving health, tuning medical treatments, and thereby saving many lives.
About Elegant Mathematics
1992 Incorporation of Elegant Mathematics Inc. in Bothell, USA (reg. nr. 601360776), active as the main supercomputer software supplier for Cray Research Inc.
2006 Relocated to Germany and the EU (as Elegant Mathematics Ltd)
2006 Since 2006 Elegant Mathematics Ltd has previously been involved in several gas detection projects alongside E-Nose (NL) and NXP;
ground penetrating radar Tier 1 development, and CUDA projects:
Nvidia GPU supercomputer solutions consulting
2017 Incorporation of Elegant Mathematics LLC, mainly for ELEGANT NMR® activity
2020 Elegant Mathematics LLC has received 3 US patents for key NMR technologies
2020 Elegant Mathematics combined NMR and chromatography technology allows the simultaneous detection of a large number of chemicals in a mixture whose
respective concentrations are in the nanomolar range, and makes possible a new generation of nuclear magnetic resonance spectrometers with nanoscale
measuring range (Elegant NMR with Elmathron)
Order Terms
Some people guess that DNP NMR is a cost-prohibitive method of analysis.
We believe that DNP NMR should be affordable and available for all laboratories and should be easy to maintain.
We offer a price of $39,990 for one standard system configuration (Elegant NMR® Basic Version):
Elmathron® Device: Measuring device in which unknown mixtures of substances are directly assayed using DNP NMR.
Computation Server: Unit in which the storage and computer processing of measurement data takes place.
Autosampler: Provides for the automated supply of samples to the Elmathron® device.
Elegant NMR® Software: User interface for the control, monitoring, and interpretation of measurements.
Software updates for eight years after purchase.
Early-bird offer: special promo price $25,000, only until August 13, 2021
We are greatly excited to invite you to be among the first to test and to place an order for our innovative Elegant NMR® with DNP, an analytical system that uses US-patented technologies to automatically separate and identify components of an unknown mixture, including novel chemicals, without any need for pure reference spectra. On top of that, the Elegant NMR is so sensitive as to require as little as 1 nl of liquid or 1 µL of gaseous input material.
This system weighs only 18 kg and can be used in any laboratory; there are no additional installation requirements that need be met before performing analyses. That is, the Elegant NMR® does not require special housing, costly temperature regulation, or any special training for its operation; our device is meant for use in ordinary laboratory conditions by ordinary laboratory personnel.
For customers who purchase a device from the very first production run, we offer a price of $25,000 for one Elegant NMR® analytical system; this special early-bird offer includes access to our computing server and also includes delivery. It does not include VAT or customs duties.
For universities and educational institutions, the early-bird price is $20,000.
To receive our early-bird pricing, you need to place an order before August 13, 2021 and prepay a deposit of 30% of the order value before August 31, 2021.
This offer includes the following:
The measuring device Elmathron®, for which we offer a two-year warranty that includes a free inspection one year after delivery.
Computer software for which no additional licenses need be purchased, with free updates through 2029.
Three years’ complimentary access to our server for collecting and processing data.
In addition, you can simultaneously purchase the following:
Vacuum pump (up to 0.1 Pa): You can order a vacuum pump from us or use a standard laboratory pump obtained from any supplier.
Dedicated computing server for collecting and interpreting spectra: You will receive free access to our server for three years, but you can also order from us a standalone server with preinstalled software, or we can suggest a hardware and operating system for your own purchase of a computational server, or we can assist you in installing our software on a server you already have.
Autosampler: The earliest delivery time is Q1/2023.
We plan to collect orders for the first batch of devices until August 13, 2021, with a shipment date no later than the end of Q2/2022.
Prompt respondents who get their orders in our very first batch with at least 5 measuring devices will have the opportunity to get their systems and databases exclusively customized for specific analysis tasks.
If we achieve at least 30 orders, we guarantee the following:
We will immediately start ordering the components required for production of the measuring device, server and other system elements.
You will receive a detailed report on production status at the end of each month.
No later than Q1/2022, we will provide you with remote access to the test version of the analytical system to trial it before shipment. You will be able to carry out remote tests on substances available in our laboratory. By mutual agreement, you can also send us your own substances for evaluation, provided those substances are not toxic or radioactive and are not prohibited for normal transportation in Germany.
After trialing the system, you will be required to pay the next 40% of the order value.
We will send you your order no later than end of Q2/2022.
After receiving your Elegant NMR, you will have one additional month to evaluate the equipment and pay the remaining 30% of the order value.
If we do not collect 30 orders by August 13th, we will cancel all orders, inform our customers, and fully refund the prepayment.
Warranty
Elegant Mathematics service includes free Elegant NMR® Software updates for eight years after purchase.
The warranty period for the basic version of the Elegant NMR® system is two years, subject to purchase from the manufacturer's warehouse and paid mandatory intermediate inspection after one year of operation.
The warranty period can be extended to as much as five years by passing annual inspections of the measuring system.
The warranty period starts from the moment the customer receives the Elegant NMR® system.
You may order a vacuum pump from us together with the system, use one already present in your laboratory, or buy one separately from a third-party company of your choice.
The vacuum pump supplied with the Elegant NMR® measuring system is not covered by the Elegant Mathematics warranty.
Standard Order Terms
Elegant Mathematics standard condition of sales and payments is:
30% - when placing the order;
30% - once the equipment has been completely assembled and tested ex-works Germany;
20% - to be paid after witnessing and acceptance of full function of your specific equipment;
20% - final payment after inspect and testing at the customers facility.
All invoices are due and payable in cash in EU or US currency. All payments due to Elegant Mathematics shall be made by bank wire transfer.
Our Contacts
Elegant Mathematics LLC,
82834, WY, USA Tel: +1 (631) 490 - 0521 Email: info at elegant - mathematics dot com
Elegant Mathematics Ltd,
Hanauer Muehle 2,
66564, Ottweiler-Fuerth,
Saarland Germany Tel: +49 (6858) 79 79 858 Email: info at elegant - math dot de
Legal registration numbers:
USA: Cheyenne 746213
UK: Cardiff 05975337
DE: HRB 16570
Active and registered since 23 Oct 2006
German tax payer's account number 030/146/00565
EU VAT account number DE 257663693
Customs number (EORI) DE 1753525
According to Par 2 Abs. 2 ElektroG, our Elegant NMR is a pure Research and Development device for university and industrial usage only; it is therefore available free from
the WEEE in the EU.
Our technical support and information office is always available for you. You can contact us at any time from any point in the world by phone and receive competitive
guidance and consulting on our products and services. Please also use our ResearchGate Project Page
to discuss aspects of the Elegant NMR, along with general questions on applied mathematics, physics, and chemistry related to NMR.
Disclaimer: By providing links to other sites, Elegant-NMR.com, Elegant-NMR.de, Elegant Mathematics Ltd, and Elegant Mathematics LLC do not guarantee, approve,
or endorse the information or products available at those sites, nor does a link indicate any association with or endorsement by the linked site of Elegant-NMR.com or
Elegant-NMR.de.
